Protein Expression Facility (PEF)

University of Queensland

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Electron micrograph of recombinantly produced virus-like particles

The Protein Expression Facility (PEF) specialises in recombinant protein production to advance cutting-edge research across academia, industry and government sectors. PEF incorporates frontier protein technologies and a team of highly skilled specialists to deliver proteins for diverse applications. With a comprehensive protein production platform and a suite of expression systems, PEF designs and develops protein production strategies for over 200 discovery and translational projects per year. A broad spectrum of protein-based products are routinely produced in milligrams or grams quantity for end-use applications such as biotherapeutic and vaccine development, biocontrol technology, structural and functional studies, and modern diagnostic. Workshops, customised upskilling programs and one-on-one consultation are also offered. PEF has been recognised with multiple awards for its service excellence and teamwork.

Website https://pef.facility.uq.edu.au/

Key science sectors

Strengths and capabilities

  • Molecular engineering strategies
  • Parallel expression optimisation in four expression hosts
  • Upstream and downstream bioprocessing engineering
  • Protein analytics and characterisation
  • Endotoxin-free DNA plasmid production
  • Baculovirus/insect cell technology
  • Transient and stable protein production
  • Analytical method development
  • Biotherapeutic and vaccine technology
  • Virus-like particle engineering and production

Facilities and major equipment

  • Molecular biology laboratory
  • Cell culture laboratory
  • Stirred-tank and rocking-motion bioreactors
  • Semi-automated tangential flow filtration system
  • Fast protein liquid chromatography purification systems
  • A suite of protein analytics

Number of research staff

Up to 20 research staff

Address

Level 2, AIBN Building (#75), The University of Queensland, St Lucia QLD 4072, Australia

Lead researchers

  • Professor Linda Lua—Founded and established PEF into the Australia's leading protein research facility that enables hundreds of researchers
  • Dr Balaji Somasundaram—Acadamic and industry downstream bioproess engineering

Achievements of the centre

Organisation type

  • University Research Centre

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