Queensland COVID-19 research

This page of Queensland’s research related to the COVID-19 pandemic is compiled from information provided by Queensland universities and research institutes.

While many of our researchers are working on potential vaccines, treatments and other medical interventions, other researchers are applying their expertise to other impacts of the pandemic upon our economy and other aspects of society. The data includes immediate research activity, recent relevant work, proposed research (subject to available funds) and other responses using the resources and expertise of our research organisations.

Listing 5 matching responses out of 142 total responses.

  • Researchers develop direct-acting antiviral therapy to treat COVID-19 May 2021

    Scientists from Menzies Health Institute Queensland and City of Hope in the US have developed an experimental direct-acting antiviral for COVID-19. They used gene-silencing RNA technology - siRNA (small-interfering RNA) to attack the virus's genome directly. This stops the virus from replicating and is delivers the siRNA to the lungs by lipid nanoparticles. This still experimental treatment was designed at Griffith University and City of Hope. The treatment reduces viral load by 99.9% and is designed to work on all betacoronaviruses such as the original SARS virus (SARS-CoV-1) as well as SARS-CoV-2 and any new variants that may arise in the future.

    #Immunology

    Centre

    Menzies Health Institute Queensland
    Griffith University

    Contact details
    Professor Nigel McMillan
    Program Director Infectious Diseases and Immunology
    n.mcmillan@griffith.edu.au
    +61 4 13 730 894
    Collaborations
    • Collaborator: Beckman Research Institute - City of Hope USA
    • Funder: Medical Research Futures Fund - Australian Government
  • Understanding T cell mediated immune control of Sars-CoV-2 and the development of a cellular immunotherapy approach for COVID-19 May 2021

    Our research team is focused upon developing an understanding of immunodominant T cell responses to Sars-CoV-2 and using this knowledge as a platform to develop T cell based immunotherapy. Associate Professor Corey Smith, head of QIMR Berghofer’s Translational and Human Immunology Group, is leading the COVID-19 Immunity study, examining how the immune systems of those who have recovered from SARS-CoV-2 responded to the virus. QIMR Berghofer researchers have received a million dollar boost to further their understanding of COVID-19 immunology from the Medical Research Future Fund (MRFF) as part of its Coronavirus Research Response.

    #Immunology

    Centre

    QIMR Berghofer Medical Research Institute

    Contact details
    Associate Professor Corey Smith
    Team Head
    corey.smith@qimrberghofer.edu.au
    +61 7 3362 0313
    Collaborations
    • The University of Queensland
    • Monash University
    • Mater Research
    • Queensland Health.
  • Understanding immunity to COVID-19. May 2021

    Professor Denise Doolan at AITHM James Cook University is part of an Australian and international collaboration to understand immunity to SARS-CoV-2 and why individuals respond differently, and to develop diagnostics for COVID-19 suitable for rapid point-of-care measurement of immunity in low transmission and resource-poor areas.

    #Immunology

    Centre

    Australian Institute of Tropical Health and Medicine
    James Cook University

    Contact details
    Professor Denise Doolan
    Professorial Research Fellow
    Denise.Doolan@jcu.edu.au
    +61 7 4232 1492
    Collaborations
    • Prof Katherine Kedzierska, Peter Doherty Institute, University of Melbourne
    • Australian National University
    • Burnet Institute, Monash University
    • The University of Queensland
  • High levels of a specific cytokines in COVID-19 severity suggest a divergence between anti-viral and pro-inflammatory T-cell responses May 2021

    This Queensland collaborative research project with several Chinese research institutes aimed to gain an understanding of the paradox of the immunity in COVID-19 patients with T cells showing both functional defects and hyperactivation and enhanced proliferation. By investigating COVID-19 patient samples and mouse models, this study demonstrates a divergent function of T cells in severe COVID?19 patients in which insufficient anti?viral immunity and pro?inflammatory T cell expansion contribute to disease severity.

    #Immunology

    Centre

    Diamantina Institute
    The University of Queensland

    Contact details
    Professor Di Yu
    Professorial Research Fellow
    di.yu@uq.edu.au
    +61 4 2333 9898
    Collaborations
    • Collaborators:
    • Professor Min Xie and her team, Department of Respiratory and Critical Care Medicine, Tongji Hospital
    • Tongji Medical College
    • Huazhong University of Science and Technology
  • Harnessing Oxidised Cholesterols to Reverse Susceptibility to COVID-19 in Diabetes August 2021

    Diabetes increases susceptibility to and severity of bacterial and viral respiratory infections. A Mater Research group led by A/Prof Katharina Ronacher recently discovered that oxidised cholesterols play an important role in the immune response to tuberculosis in the lung. They are now investigating the role that oxidized cholesterols, so called oxysterols, play in the immune response to SARS-CoV-2 and COVID-19 severity in presence and absence of diabetes. This study will significantly advance our knowledge in respiratory infection research by establishing the biological significance of oxidised cholesterols and the benefits of modulating oxysterol activity to improve respiratory infection outcomes.

    #Immunology

    Centre

    Mater Research Institute
    The University of Queensland

    Contact details
    Associate Professor Katharina Ronacher
    Principal Research Fellow
    katharina.ronacher@mater.uq.edu.au
    +61 7 3443 7633
    Collaborations

Other Queensland COVID-19 initiatives

Queensland Government
Coronavirus (COVID-19) business assistance finder
Life Sciences Queensland
Life Sciences Queensland joins the data-powered alliance to stop COVID-19

Key Australian COVID-19 initiatives

Australian Academy of Science
Rapid Research Information Forum (RRIF)
COVID-19 Expert Database

Key international COVID-19 initiatives

CORD-19 (COVID-19 Open Research Dataset)
Free database of 130,000 plus COVID-19 open research papers